Best Practice Advice AC7-01

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Aerosol deposition in the human upper airways

Application Challenge AC7-01   © copyright ERCOFTAC 2019

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Key Fluid Physics and Deposition Mechanisms

Airflow in the human upper airways transitions to turbulence due to geometric effects, such as the bent in the oropharyngeal region and the constriction at the glottis. The bent in the oropharynx causes substantial filtering of inhaled aerosols due to inertial impaction on the airway walls. Filtering in the extrathoracic airways increases as the particle size and inhalation flowrate increase.

As we move in the tracheobronchial airways, the Reynolds number is reduced because the air travels through a larger total cross-sectional area. As a result, airflow relaminarizes in the first generations. At the flowrate examined in the present AC, the main deposition mechanism in this region is inertial impaction, with significant deposition at the bents and the bifurcations. At lower flowrates, deposition can also be influenced by gravitational sedimentation because the residence times of the particles in the bronchial airways is longer.

Application Uncertainties

The differences between measurements and simulations can result from several uncertainties involved in the tests. A first source of uncertainty are the in vitro inlet conditions, which might be different from the velocity and particle profiles assumed in the CFD simulations. In the experimental setup, various devices were placed upstream of the mouth inlet (see figure 5) and these devices are expected to alter the inlet flow and particle conditions from what is prescribed in the simulations.

Another source of uncertainty between the experiment and the simulations is the size of the particles. Monodisperse particles have been assumed in the simulations whereas the aerosols generated in the experiments had a standard geometric deviation of size smaller than 1.24μm.

Computational Domain and Boundary Conditions

The geometry of the extrathoracic airways must be included because turbulence is generated in this region and alters transport and deposition of particles in the distal airways. In addition, significant filtering occurs in the mouth and throat, which affects the amount of inhaled aerosols that will eventually reach the desirable lung generations. In the present AC, in both LES and RANS tests the inlet at the mouth of the model was extruded in order to generate turbulent velocity conditions. This strategy was adopted due to the absence of a more realistic inlet velocity profile.

Concerning the boundary conditions, the inlet velocity profile and the particle distribution are important determinants of particle deposition and thus realistic inlet conditions should be used. At the outlets, it is important to apply correct pressures such that the ventilation of the airway tree is realistic. Otherwise, both the air and particle distribution in the trachea will not be predicted accurately.

In the LES simulations, the volumetric flowrates at the 10 terminal outlets are prescribed based on the values measured in vitro (Table 3). These outlet conditions result in high asymmetry in the ventilation of the two lungs: the left lung receives 29% of the inhaled air whereas the right lung receives 71%.

In the RANS calculations, a simplified boundary condition setup was applied. Instead of applying prescribed flowrates at the outlets of the system similarly to the experiments, a simpler strategy of applying the flowrate at the inlet and zero pressure at the outlets was used. Using these boundary conditions, an overall good agreement with the experimental data was observed with small differences on the ventilation distribution after the third branching level. This approach may be used to obtain preliminary results, however, the correct application of the flow field for all the outlets is recommended in future works to better predict the flow in the further downstream located sections of the system.



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