Difference between revisions of "Best Practice Advice AC7-01"

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Line 48: Line 48:
  
 
In the LES simulations, the volumetric flowrates at the 10 terminal outlets are prescribed based
 
In the LES simulations, the volumetric flowrates at the 10 terminal outlets are prescribed based
on the values measured ''in vitro'' ([[Description_AC7-01#table3|Table 3]]).
+
on the values measured ''in vitro'' ([[Test_Data_AC7-01#table3|Table 3]]).
 
These outlet conditions result
 
These outlet conditions result
 
in high asymmetry in the ventilation of the two lungs: the left lung receives 29% of the
 
in high asymmetry in the ventilation of the two lungs: the left lung receives 29% of the
Line 73: Line 73:
 
tracking. Recommended values for the parameters involved in mesh generation (initial cell
 
tracking. Recommended values for the parameters involved in mesh generation (initial cell
 
height, average expansion ratio, number of near-wall prism layers, average cell volume in
 
height, average expansion ratio, number of near-wall prism layers, average cell volume in
the domain, number of computational cells etc.) can be found in Table 5.
+
the domain, number of computational cells etc.) can be found in
 +
[[CFD_Simulations_AC7-01#table5|Table 5]].
 +
 
 
==Physical Modelling==
 
==Physical Modelling==
 
===Turbulence models===
 
===Turbulence models===
 
In the LES simulations, the dynamic version of the Smagorinsky-Lilly subgrid scale model
 
In the LES simulations, the dynamic version of the Smagorinsky-Lilly subgrid scale model
(Lilly, 1992) is adopted in order to examine the unsteady flow in the realistic airway
+
([[Best_Practice_Advice_AC7-01#lilly1992|Lilly, 1992]])
 +
is adopted in order to examine the unsteady flow in the realistic airway
 
geometries. Previous studies have shown that this model performs well in transitional
 
geometries. Previous studies have shown that this model performs well in transitional
flows in the human airways (Radhakrishnan & Kassinos, 2009; Koullapis ''et al.'', 2016).
+
flows in the human airways
 +
([[Best_Practice_Advice_AC7-01#radhakrishnan2009|Radhakrishnan & Kassinos, 2009]];
 +
[[Best_Practice_Advice_AC7-01#koullapis2016|Koullapis ''et al.'', 2016]]).
  
For the RANS simulations, the standard k-ω SST turbulence model is used due to
+
For the RANS simulations, the standard ''k-ω'' SST turbulence model is used due to
its good prediction of such wall—bounded flow (i.e. using a blending between wall and
+
its good prediction of such wall-bounded flow (i.e. using a blending between wall and
 
free-stream region) and low computational cost. Other turbulence models have not been
 
free-stream region) and low computational cost. Other turbulence models have not been
 
considered but based on prior experince they are exprected to perform worse.
 
considered but based on prior experince they are exprected to perform worse.
Line 96: Line 101:
 
are important when considering the transport of micron—sized particles in the human
 
are important when considering the transport of micron—sized particles in the human
 
airways. This is mainly because the particle density is much greater than the density of
 
airways. This is mainly because the particle density is much greater than the density of
the air (''&rho;<sub>p</sub>''&nbsp;/&nbsp;''&rho;<sub>f</sub>''&nbsp;&ge;&nbsp;1000).
+
the air
 +
<math>{(\rho_p/\rho_f\ge 1000)}</math>.
 
Furthermore, in numerical simulations the particles are assumed
 
Furthermore, in numerical simulations the particles are assumed
 
spherical and, as a result, the important forces that need to be taken into account in lung
 
spherical and, as a result, the important forces that need to be taken into account in lung
 
deposition studies are drag, gravity and Brownian motion force. However, Lift force due
 
deposition studies are drag, gravity and Brownian motion force. However, Lift force due
 
to shear can also be important as particle size increases. This is evident in figure 21, that
 
to shear can also be important as particle size increases. This is evident in figure 21, that
plots deposition fraction in the mouth—throat / trachea (segments 1&2) of the benchmark
+
plots deposition fraction in the mouth-throat / trachea (segments 1&2) of the benchmark
geometry for three particle sizes (1, 4.3 and 10&mu;m) at a flowrate of 60 L / min (LES results).
+
geometry for three particle sizes (1, 4.3 and 10<math>{\mu m}</math>) at a flowrate of
In this case, the expression for the shear lift is obtained by Saflman (1965), Saflman (1968)
+
60 L / min (LES results).
and Mei (1992). It is observed that the Saflman lift force results in an increase in the
+
In this case, the expression for the shear lift is obtained by
deposition of 10&mu;m particles by approximately 5%.
+
[[Best_Practice_Advice_AC7-01#saffman1965|Saffman&nbsp;(1965)]],
 +
[[Best_Practice_Advice_AC7-01#saffman1968|Saffman&nbsp;(1968)]]
 +
and [[Best_Practice_Advice_AC7-01#mei1992|Mei&nbsp;(1992)]].
 +
It is observed that the Saffman lift force results in an increase in the
 +
deposition of 10<math>{\mu m}</math> particles by approximately 5%.
  
  
Line 113: Line 123:
 
|align="center"|[[Image:AC7-01_fig21.png|650px]]
 
|align="center"|[[Image:AC7-01_fig21.png|650px]]
 
|-
 
|-
|align="left"|'''Figure 21:''' LES predictions of Deposition fraction in the mouth—throat / trachea (segments 1&2) of the benchmark geometry for three particle sizes (1, 4.3 and 100<math>{\mu}</math>m) at a flowrate of 60 L/min.
+
|align="left" width=650|'''Figure 21:''' LES predictions of Deposition fraction in the mouth-throat / trachea (segments 1&2) of the benchmark geometry for three particle sizes (1, 4.3 and 100<math>{\mu}</math>m) at a flowrate of 60 L/min.
 
|}
 
|}
  
Line 128: Line 138:
 
In our LES the grid size is larger than the Kolmogorov scale and thus this
 
In our LES the grid size is larger than the Kolmogorov scale and thus this
 
condition is satisfied. Specifically, the minimum ratio of resolved scales (mesh size near
 
condition is satisfied. Specifically, the minimum ratio of resolved scales (mesh size near
the wall) to the particle size is 40 for 1&mu;m particles and 4 for 10&mu;m.
+
the wall) to the particle size is 40 for 1<math>{\mu m}</math> particles and
 +
4 for 10<math>{\mu m}</math>.
  
 
In point-particle LES, the resolved velocities are used in the calculation of the forces
 
In point-particle LES, the resolved velocities are used in the calculation of the forces
Line 137: Line 148:
 
deposition in the airways has not been investigated.
 
deposition in the airways has not been investigated.
  
Armenio ''et&nbsp;al.'' (1999) examined the effects of small-scale velocity fluctuations on the
+
[[Best_Practice_Advice_AC7-01#armenio1999|Armenio&nbsp;''et&nbsp;al.''&nbsp;(1999)]]
 +
examined the effects of small-scale velocity fluctuations on the
 
motion of tracer and inertial particles in a turbulent channel flow at
 
motion of tracer and inertial particles in a turbulent channel flow at
Re<sub>&tau;</sub>&nbsp;=&nbsp;175.
+
<math>{Re_\tau=175}</math>.
 
They concluded that well-resolved LES with an adequate LES model can provide fairly accurate
 
They concluded that well-resolved LES with an adequate LES model can provide fairly accurate
 
particle statistics for moderate Reynolds number flows. They also observed that errors in
 
particle statistics for moderate Reynolds number flows. They also observed that errors in
Line 145: Line 157:
 
errors. Specifically, good agreement in dispersion statistics was found between DNS and
 
errors. Specifically, good agreement in dispersion statistics was found between DNS and
 
well-resolved LES with the dynamic model (differences less than 8%) whereas rather higher
 
well-resolved LES with the dynamic model (differences less than 8%) whereas rather higher
errors were recorded for the coarser meshes. The study of Armenio ''et&nbsp;al.'' (1999) provides
+
errors were recorded for the coarser meshes. The study of
 +
[[Best_Practice_Advice_AC7-01#armenio1999|Armenio&nbsp;''et&nbsp;al.''&nbsp;(1999)]] provides
 
conservative estimates of the accuracy of LES in the prediction of particle-laden flow since
 
conservative estimates of the accuracy of LES in the prediction of particle-laden flow since
 
tracer particles were used, which are the most sensitive to the small-scale fluctuations, In
 
tracer particles were used, which are the most sensitive to the small-scale fluctuations, In
Line 160: Line 173:
  
 
In the RANS simulations, the minimum ratio of resolved scales (mesh size near the
 
In the RANS simulations, the minimum ratio of resolved scales (mesh size near the
wall) to the particle size is 30 for 1&mu;m particles and 3 for 10&mu;m and therefore the particles
+
wall) to the particle size is 30 for 1<math>{\mu m}</math> particles and 3 for
 +
10<math>{\mu m}</math> and therefore the particles
 
can be considered as point-particles and Lagrangian simulations can be performed. For
 
can be considered as point-particles and Lagrangian simulations can be performed. For
 
particle tracking in RANS simulations, the generation of the fluid fluctuating velocity
 
particle tracking in RANS simulations, the generation of the fluid fluctuating velocity
Line 193: Line 207:
 
&lsquo;Simulation and pharmaceutical technologies for advanced patient-tailored inhaled
 
&lsquo;Simulation and pharmaceutical technologies for advanced patient-tailored inhaled
 
medicines&rsquo;, supported by COST (European Cooperation in Science and
 
medicines&rsquo;, supported by COST (European Cooperation in Science and
Technology&nbsp;—&nbsp;www.cost.eu).
+
Technology&nbsp;—&nbsp;[https://www.cost.eu www.cost.eu]).
 +
 
 
==References==
 
==References==
Armenio, V., Piomelli, U. & Fiorotto, V. 1999 Effect of the subgrid scales on particle
+
<div id="armenio1999"></div>
motion. ''Physics of Fluids'' '''11''' (10), 3030&nbsp;&ndash;&nbsp;3042.
+
Armenio, V., Piomelli, U. & Fiorotto, V. 1999
 +
:Effect of the subgrid scales on particle motion. ''Physics of Fluids'' '''11''' (10), 3030&nbsp;&ndash;&nbsp;3042.
  
  
Line 218: Line 234:
 
:''The Mechanics of Inhaled Pharmaceutical Aerosols''. Academic Press, New York.
 
:''The Mechanics of Inhaled Pharmaceutical Aerosols''. Academic Press, New York.
  
Jasak, H. 1996 Error analysis and estimation for the finite volume method with applications to fluid flows. PhD thesis, Department of Mechanical Engineering, Imperial
+
 
College of Science, Technology and Medicine, London, UK.
+
<div id="jasak1996"></div>
 +
Jasak, H. 1996
 +
:Error analysis and estimation for the finite volume method with applications to fluid flows. PhD thesis, Department of Mechanical Engineering, Imperial College of Science, Technology and Medicine, London, UK.
  
  
Line 286: Line 304:
 
:The lift on a small sphere in a slow shear flow. ''Journal of Fluid Mechanics'' '''22''' (2), 385&nbsp;&ndash;&nbsp;400.
 
:The lift on a small sphere in a slow shear flow. ''Journal of Fluid Mechanics'' '''22''' (2), 385&nbsp;&ndash;&nbsp;400.
  
Saffman, P. G. 1968 The lift on a small sphere in a slow shear flow corrigendum. Journal
+
 
of Fluid Mechanics 31 (3), 6247624.
+
<div id="saffman1968"></div>
 +
Saffman, P. G. 1968
 +
:The lift on a small sphere in a slow shear flow &ndash; corrigendum. ''Journal of Fluid Mechanics'' '''31''' (3), 624&nbsp;&ndash;&nbsp;624.
  
  
Line 297: Line 317:
 
<div id="schmidt2004"></div>
 
<div id="schmidt2004"></div>
 
Schmidt, Andreas, Zidowitz, Stephan, Kriete, Andres, Denhard, Thorsten, Krass, Stefan
 
Schmidt, Andreas, Zidowitz, Stephan, Kriete, Andres, Denhard, Thorsten, Krass, Stefan
& Peitgen, Heinz—Otto 2004
+
& Peitgen, Heinz-Otto 2004
 
:A digital reference model of the human bronchial tree. ''Computerized Medical Imaging and Graphics'' '''28''' (4), 203&nbsp;&ndash;&nbsp;211.
 
:A digital reference model of the human bronchial tree. ''Computerized Medical Imaging and Graphics'' '''28''' (4), 203&nbsp;&ndash;&nbsp;211.
  

Revision as of 11:11, 10 October 2019

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Best Practice Advice

Aerosol deposition in the human upper airways

Application Challenge AC7-01   © copyright ERCOFTAC 2019

Best Practice Advice

Key Fluid Physics and Deposition Mechanisms

Airflow in the human upper airways transitions to turbulence due to geometric effects, such as the bent in the oropharyngeal region and the constriction at the glottis. The bent in the oropharynx causes substantial filtering of inhaled aerosols due to inertial impaction on the airway walls. Filtering in the extrathoracic airways increases as the particle size and inhalation flowrate increase.

As we move in the tracheobronchial airways, the Reynolds number is reduced because the air travels through a larger total cross-sectional area. As a result, airflow relaminarizes in the first generations. At the flowrate examined in the present AC, the main deposition mechanism in this region is inertial impaction, with significant deposition at the bents and the bifurcations. At lower flowrates, deposition can also be influenced by gravitational sedimentation because the residence times of the particles in the bronchial airways is longer.

Application Uncertainties

The differences between measurements and simulations can result from several uncertainties involved in the tests. A first source of uncertainty are the in vitro inlet conditions, which might be different from the velocity and particle profiles assumed in the CFD simulations. In the experimental setup, various devices were placed upstream of the mouth inlet (see figure 5) and these devices are expected to alter the inlet flow and particle conditions from what is prescribed in the simulations.

Another source of uncertainty between the experiment and the simulations is the size of the particles. Monodisperse particles have been assumed in the simulations whereas the aerosols generated in the experiments had a standard geometric deviation of size smaller than .

Computational Domain and Boundary Conditions

The geometry of the extrathoracic airways must be included because turbulence is generated in this region and alters transport and deposition of particles in the distal airways. In addition, significant filtering occurs in the mouth and throat, which affects the amount of inhaled aerosols that will eventually reach the desirable lung generations. In the present AC, in both LES and RANS tests the inlet at the mouth of the model was extruded in order to generate turbulent velocity conditions. This strategy was adopted due to the absence of a more realistic inlet velocity profile.

Concerning the boundary conditions, the inlet velocity profile and the particle distribution are important determinants of particle deposition and thus realistic inlet conditions should be used. At the outlets, it is important to apply correct pressures such that the ventilation of the airway tree is realistic. Otherwise, both the air and particle distribution in the trachea will not be predicted accurately.

In the LES simulations, the volumetric flowrates at the 10 terminal outlets are prescribed based on the values measured in vitro (Table 3). These outlet conditions result in high asymmetry in the ventilation of the two lungs: the left lung receives 29% of the inhaled air whereas the right lung receives 71%.

In the RANS calculations, a simplified boundary condition setup was applied. Instead of applying prescribed flowrates at the outlets of the system similarly to the experiments, a simpler strategy of applying the flowrate at the inlet and zero pressure at the outlets was used. Using these boundary conditions, an overall good agreement with the experimental data was observed with small differences on the ventilation distribution after the third branching level. This approach may be used to obtain preliminary results, however, the correct application of the flow field for all the outlets is recommended in future works to better predict the flow in the further downstream located sections of the system.

Discretisation and Grid Resolution

Since it is not possible to generate a structured hexahedral grid for the present geometry due to its complexity, a higher refinement ratio should be applied to avoid numerical diffusion. In addition to that, layers of prismatic elements should be added near the wall boundaries for a better prediction of this region, not only with regard to flow properties itself, but the flow conditions seen by the particles, i.e. mean velocity and turbulence properties. Despite the application of interpolated properties for the particle positions, a better agreement was observed when a refinement was applied to the wall layers. Hence, a finer grid in the vicinity of the wall is recommended for allowing more accurate particle tracking. Recommended values for the parameters involved in mesh generation (initial cell height, average expansion ratio, number of near-wall prism layers, average cell volume in the domain, number of computational cells etc.) can be found in Table 5.

Physical Modelling

Turbulence models

In the LES simulations, the dynamic version of the Smagorinsky-Lilly subgrid scale model (Lilly, 1992) is adopted in order to examine the unsteady flow in the realistic airway geometries. Previous studies have shown that this model performs well in transitional flows in the human airways (Radhakrishnan & Kassinos, 2009; Koullapis et al., 2016).

For the RANS simulations, the standard k-ω SST turbulence model is used due to its good prediction of such wall-bounded flow (i.e. using a blending between wall and free-stream region) and low computational cost. Other turbulence models have not been considered but based on prior experince they are exprected to perform worse.

In order to better validate the numerical predictions of LES and RANS, a second application challenge will follow that will focus on airflow characteristics in the same geometry. Moreover, in this second AC, numerical predictions will be compared against PIV measurements.

Lagrangian particle tracking

Lagrangian particle tracking has been adopted in the present application. Although there is a number of forces acting on the particles (Drag, buoyancy, Basset (or history), pressure gradient force, lift due to shear and rotation and Brownian forces), only few of them are important when considering the transport of micron—sized particles in the human airways. This is mainly because the particle density is much greater than the density of the air . Furthermore, in numerical simulations the particles are assumed spherical and, as a result, the important forces that need to be taken into account in lung deposition studies are drag, gravity and Brownian motion force. However, Lift force due to shear can also be important as particle size increases. This is evident in figure 21, that plots deposition fraction in the mouth-throat / trachea (segments 1&2) of the benchmark geometry for three particle sizes (1, 4.3 and 10) at a flowrate of 60 L / min (LES results). In this case, the expression for the shear lift is obtained by Saffman (1965), Saffman (1968) and Mei (1992). It is observed that the Saffman lift force results in an increase in the deposition of 10 particles by approximately 5%.


AC7-01 fig21.png
Figure 21: LES predictions of Deposition fraction in the mouth-throat / trachea (segments 1&2) of the benchmark geometry for three particle sizes (1, 4.3 and 100m) at a flowrate of 60 L/min.


As described in the discrete phase modelling, the time step of the particle tracking calculation should automatically and independently be adapted along the trajectories by considering all relevant time scales, which are also changing throughout the flow field. This allows for numerically eflicient particle tracking. If such an approach is not possible, a verification of the relevant time scales should be calculated by using averaged values in order to apply a correct time step for the simulations.

Modelling of unresolved flow velocities

In Lagrangian point-particle methods the particle size must be smaller that the Kolmogorov scale. In our LES the grid size is larger than the Kolmogorov scale and thus this condition is satisfied. Specifically, the minimum ratio of resolved scales (mesh size near the wall) to the particle size is 40 for 1 particles and 4 for 10.

In point-particle LES, the resolved velocities are used in the calculation of the forces acting on the particles whereas the unresolved part of the air velocities is lost due to the filtering procedure. Thus, the effect of the small-scale (unresolved) motion on particle dispersion and deposition must be either modelled separately, or neglected. In the present LES calculations, the effect of the unresolved scales of the continuous phase on particle deposition in the airways has not been investigated.

Armenio et al. (1999) examined the effects of small-scale velocity fluctuations on the motion of tracer and inertial particles in a turbulent channel flow at . They concluded that well-resolved LES with an adequate LES model can provide fairly accurate particle statistics for moderate Reynolds number flows. They also observed that errors in LES are mainly attributed to the LES filtering operation rather than to sub-grid modelling errors. Specifically, good agreement in dispersion statistics was found between DNS and well-resolved LES with the dynamic model (differences less than 8%) whereas rather higher errors were recorded for the coarser meshes. The study of Armenio et al. (1999) provides conservative estimates of the accuracy of LES in the prediction of particle-laden flow since tracer particles were used, which are the most sensitive to the small-scale fluctuations, In the case of particles with inertia, the errors are expected to be smaller.

In the present application challenge, airflow Reynolds numbers are low to moderate in the extrathoracic airways and the motion of inertial particles is simulated. Therefore, it is expected that if sufficient mesh resolution is employed then a model for accounting the effect of the unresolved scales on particle motion is not necessary. However, there are cases where the inhalation flowrate and thus the Reynolds number is higher, such as the inhalation from low-resistance inhalers, coughing etc. Therefore, further studies are needed to determine the conditions under which a model accounting for the effect of the unresolved scales on particle motion is required.

In the RANS simulations, the minimum ratio of resolved scales (mesh size near the wall) to the particle size is 30 for 1 particles and 3 for 10 and therefore the particles can be considered as point-particles and Lagrangian simulations can be performed. For particle tracking in RANS simulations, the generation of the fluid fluctuating velocity acting on the particle is an essential step, which in this study has been done assuming isotropic turbulence. Moreover, the relevant turbulent time and length scales have been determined based on this assumption. Nevertheless, a spurious drift may occur driving fine particles to the wall and unrealistically enhancing deposition. This spurious drift has to be corrected appropriately.

Recommendations for Future Work

The present application challenge focuses on aerosol deposition and the airflow in the geometry has not been studied. In order to better validate the numerical predictions of LES and RANS, a second application challenge will follow that will focus on airflow characteristics in the same geometry. Moreover, in this second AC, numerical predictions will be compared against PIV measurements.

Concerning the dispersed phase, it is known that forces due to collision between particles become important in the case of dense aerosol suspensions. In other words, as the volume fraction of the particle phase increases, collisions between particles influence the simulation results. In addition, the flow is affected by the presence of the particles and thus particle force source terms must be included in the momentum equations of the fluid phase. This case is known as four-way coupling. If the particle volume fraction is sufficiently low, the particles do not collide with each other and also the flow remains unaffected by their presence. This is known as one-way coupling. In an intermediate state, named two-way coupling, the flow is affected by the particles, but particle collisions do not have significant impact and therefore collision effects can be discarded in the simulation. The limits of validity of the coupling regimes are reported by Elghobashi (1994). In the present study, we have assumed one-way coupling, however, it is important to examine how deposition in the human airways is influenced when two- and four-way coupling effects are present.

Acknowledgements

The present application challenge is based upon work from COST Action MP1404 SimInhale ‘Simulation and pharmaceutical technologies for advanced patient-tailored inhaled medicines’, supported by COST (European Cooperation in Science and Technology — www.cost.eu).

References

Armenio, V., Piomelli, U. & Fiorotto, V. 1999

Effect of the subgrid scales on particle motion. Physics of Fluids 11 (10), 3030 – 3042.


Baker, T. J. 2003

Interpolation from a cloud of points. pp. 55 – 63. Santa Fe, New Mexico.


Chan, Tai & Lippmann, Morton 1980

Experimental measurements and empirical modelling of the regional deposition of inhaled particles in humans. American Industrial Hygiene Association Journal 41 (6), 399 – 409.


Crowe, C. T., Schwarzkopf, J. D., Sommerfeld, M. & Tsuji, Y. 2012

Multiphase flows with droplets and particles. CRC Press.


Finlay, W. H. 2001

The Mechanics of Inhaled Pharmaceutical Aerosols. Academic Press, New York.


Jasak, H. 1996

Error analysis and estimation for the finite volume method with applications to fluid flows. PhD thesis, Department of Mechanical Engineering, Imperial College of Science, Technology and Medicine, London, UK.


Von Karman, T. & Horwarth, L., ed. 1938

On the statistical theory of isotropic turbulence, vol. A164. Proc. Royal Society London.


Koullapis, P., Kassinos, S. C., Muela, J., Perez-Segarra, C., Rigola, J., Lehmkuhl, 0., Cui, Y., Sommerfeld, M., Elcner, J., Jicha, M., Saveljic, I., Filipovic, N., Lizal, F. & Nicolaou, L. 2018

Regional aerosol deposition in the human airways: The siminhale benchmark case and a critical assessment of in silico methods. European Journal of Pharmaceutical Sciences 113, 77 – 94.


Koullapis, P. G., Kassinos, S.C., Bivolarova, M. P. & Melikov, A. K. 2016

Particle deposition in a realistic geometry of the human conducting airways: Effects of inlet velocity profile, inhalation flowrate and electrostatic charge. Journal of Biomechanics 49, 2201 – 2212.


Legg, B. J. & Raupach, M.R,. 1982

Markov-chain simulations of particle dispersion in inhomogeneous flows: The mean drift velocity induced by a gradient eulerian velocity variance. Boundary-Layer Meteorology 24 (3 – 13).


Li, A. & Ahmadi, G. 1992

Dispersion and deposition of spherical particles from point sources in a turbulent channel flow. Aerosol Science and Technology 16, 2097226.


Lilly, D. K. 1992

A proposed modification of the Germano subgrid-scale closure method. Physics of Fluids A 4 (3), 6337635.


Lizal, Frantisek, Belka, Miloslav, Adam, Jan, Jedelsky, Jan & Jicha, Miroslav 2015

A method for in vitro regional aerosol deposition measurement in a model of the human tracheobronchial tree by the positron emission tomography. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 229 (10),750 – 757.


Lizal, Frantisek, Elcner, Jakub, Hopke, Philip K, Jedelsky, Jan & Jicha, Miroslav 2012

Development of a realistic human airway model. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 226 (3), 197 – 207.


Macpherson, G. B., Nordin, N. & Weller, G. 2009

Particle tracking in unstructured, arbitrary polyhedral meshes for use in CFD and molecular dynamics. Communications in Numerical Methods in Engineering 25 (3), 263 – 273.


Matida, E. A., Finlay, W. H., Lange, C. F. & Grgic, B. 2004

Improved numerical simulation of aerosol deposition in an idealized mouth-throat. Aerosol Science 35, 1 – 19.


Mei, R. 1992

An approximate expression for the shear lift force on a spherical particle at finite reynolds number. International Journal of Multiphase Flow 18 (1), 145 – 147.


Radhakrishnan, H. & Kassinos, S. 2009

CFD modeling of turbulent flow and particle deposition in human lungs. 31st Annual International Conference of the IEEE EMBS, Mineapolis, Minnesota, USA pp. 2867 – 2870.


Saffman, P. G. 1965

The lift on a small sphere in a slow shear flow. Journal of Fluid Mechanics 22 (2), 385 – 400.


Saffman, P. G. 1968

The lift on a small sphere in a slow shear flow – corrigendum. Journal of Fluid Mechanics 31 (3), 624 – 624.


Schiller, L. & Naumann, Z. 1935

Ver. Deutsch Ing.


Schmidt, Andreas, Zidowitz, Stephan, Kriete, Andres, Denhard, Thorsten, Krass, Stefan & Peitgen, Heinz-Otto 2004

A digital reference model of the human bronchial tree. Computerized Medical Imaging and Graphics 28 (4), 203 – 211.


SOMMERFELD, M., KOHNEN, G. & RUGER, M., ed. 1993

Some open questions and inconsistencies of Lagrangian particles dispersion models, Kyoto, Japan. Ninth symposium on Turbulence Shear Flows.


Sommerfeld, M., van Wachem, B. & Oliemans, R. 2008

Best Practice Guidelines for Computational Fluid Dynamics of Dispersed Multiphase Flows, ISBN 978-91-633-3564-8 edn. ERCOFTAC (European Research Community on Flow, Turbulence and Combustion).


Tabor, G. R.., Baba-Ahmadi, M. H., de Villiers, E. & Weller, H. G. 2004

Construction of inlet conditions for LES of turbulent channel flow. European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS).


Zhou, Yue & Cheng, Yung-Sung 2005

Particle deposition in a cast of human tracheobronchial airways. Aerosol Science and Technology 39 (6), 492 – 500.




Contributed by: *** — ***

Front Page

Description

Test Data

CFD Simulations

Evaluation

Best Practice Advice